Author(s):
1. Pero Sailović, Tehnološki fakultet Univerziteta u Banjoj Luci, Republic of Srpska, Bosnia and Herzegovina

Abstract:
Obtaining bandage with biological activity is one of the most interesting trends in the development of new medical materials. This paper investigates the impact of ceftriaxone solution concentration on the sorption during the process of obtaining biologically active fibers. The sorption of the drug was performed on the samples of oxidized cellulose (OC) with different content of carboxylic groups in an aqueous solution of ceftriaxone in concentration of c=1,7∙10-3 and 3,4∙10-3 mol / L at room temperature (22 ± 2° C) while the desorption was carried out in physiological solution. The amounts of bound and released drug were determined by spectrophotometry in UV spectrum. It was found that the content of carboxyl groups on OC, ceftriaxone solution concentration from which the sorption is carried out and the pH value influence the amount of bound drug. The results of the conducted experiment indicate that the maximum amount of bound drug (57,202 mg/g) obtained during the sorption from the solution is c=5,1∙10-3 mol/L and the maximum amount of drug released for the same sample is 3,320 mg/g.

Key words:
ceftriaxone, modified cellulose, sorption of antibiotics, impact of concentration of drug

Thematic field:
General and Applied Chemistry

Date of abstract submission:
15.07.2016.

Conference:
XI Savjetovanje hemičara, tehnologa i ekologa Republike Srpske

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